Oamenii de știință dezvăluie noi potențiale ținte terapeutice pentru tulburările mentale și neurologice

Cilii sunt structuri mici, asemănătoare părului, care se găsesc pe suprafața celulelor din corp. Se știe că joacă roluri importante în diferite funcții ale corpului, cum ar fi detectarea mediului și fluidele în mișcare. În creier, cilii au un rol important în striatul, o regiune implicată în mișcare, motivație și percepția timpului. Cercetări recente au arătat că cilii din striat joacă un rol cheie în capacitatea noastră de a percepe timpul,

Cercetătorii UCI au descoperit rolul critic al cililor în striatul în percepția timpului.

Un studiu recent al cercetătorilor de la Universitatea din California, Irvine S-a constatat că îndepărtarea cililor din regiunea striata a creierului a afectat negativ percepția și judecata timpului, ceea ce a deschis posibilitatea unor noi ținte terapeutice pentru afecțiuni mentale și neurologice, cum ar fi schizofrenia, bolile Parkinson și Huntington,[{” attribute=””>autism spectrum disorder, and Tourette syndrome.

The striatum is responsible for processing and integrating new sensory information from the environment and coordinating the sequence of motor responses. In individuals with mental and neurological disorders, there is often a significant decline in the ability to adapt to changes in the environment and correctly estimate the timing and completion of voluntary actions.

The study, which was recently published in the journal Molecular Neurobiology, uncovered the first evidence of the important role cilia play in timing-dependent dysfunction.

“Our findings may revolutionize our understanding of brain functions and mental disorders in the context of the critical task performed by these previously unappreciated organelles in the brain’s ‘central clock’ function,” said Amal Alachkar, Ph.D., corresponding author, and professor of teaching in UCI’s Department of Pharmaceutical Sciences. “Our results may open new avenues for effective intervention through cilia-targeted therapies for treatment.”

The striatum is part of the brain’s circuitry that performs central clock processes, essential in controlling executive functions such as motor coordination, learning, planning, and decision-making, as well as working memory and attention. Cilia protrude from the brain cell surfaces like antennae, working as a signaling hub that senses and transmits signals to generate appropriate reactions.

To examine their physiological role, the researchers removed cilia from the striatum in mice using conditional gene manipulation technology. These rodents were not able to learn new motor tasks, showed repetitive motor behavior, and exhibited delays in decision-making. They were also deficient in rapidly recalling information about their location and orientation in space and in their ability to filter irrelevant environmental sensory information. However, the mice maintained habitual or already learned motor skills and long-term memories.

“Successful performance of working memory, attention, decision-making, and executive function requires accurate and precise timing judgment, usually within a millisecond to a minute,” Alachkar said. “When that capacity is impaired, it means losing the ability to quickly adjust behavior in response to changes in external stimuli and failing to sustain appropriate, goal-oriented motor responses. Our ongoing work is aimed at understanding the mechanisms by which cilia regulate time perception and developing targeted therapies to improve behavioral deficits.”

Reference: “Cilia in the Striatum Mediate Timing-Dependent Functions” by Wedad Alhassen, Sammy Alhassen, Jiaqi Chen, Roudabeh Vakil Monfared and Amal Alachkar, 2 November 2022, Molecular Neurobiology.
DOI: 10.1007/s12035-022-03095-9

The study was funded by the National Institutes of Health.